Peristrophe paniculata is one of the traditional medicinal plant have been using in treatment of different diseases. The present study was carried out to provide scientific evidence about its medicinal use and phytochemical variation in different parts (stem, leaves and root) of it. Phytochemical studies were carried out for hexane, ethyl acetate and hydro alcoholic extracts using standard test procedures and antioxidant activity was carried on different free radicals i.e., superoxide, hydroxyl and 1, 1- diphenyl-2-picrylhydrazyl (DPPH). Hydroalcoholic, ethyl acetate and hexane extracts of P. paniculata were found to possess concentration dependent free radical scavenging activity on superoxide, hydroxyl and DPPH free radicals. Qualitative phytochemical screening of P. paniculata extracts revealed the presence of diverse in phytochemical constituents like steroids, terpenoids, flavonoids, alkaloids, glycosides, phenols, tannins and carbohydrates. The extracts of different parts gave negative and positive results for the amino acids, oils and saponins. The selected plant extracts showed concentration dependent percentage of inhibition on tested free radicals along with the standard drug ascorbic acid. The hexane extract of all parts of P. paniculata showed lower activity compared to ethyl acetate and hydroalcoholic extracts. Hydroalcoholic extract showed better activity. The variation in the activity and phytochemical constituents in them maybe due to the compounds present in them either as individually or in mixtures. The further research is need to evaluate more pharmacological activities and in isolation of the bioactive compounds from P. paniculata.
Srikanth M, Devi B, Kotirataiah K, Ramanjaneyulu M, Sulthana PN and Suma RR
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