Abstract

Effect of Oat Forthe Treatment of Hypertriglyceridemia; Randomized Controlled Trial

Introduction: In Mexico, the cardiovascular diseases constitute the first cause of death, from which 56% are from Coronary artery disease, having a very stretch relation with Dyslipidemia.

Objective: To determine if the oat extract is effective, safe, and well tolerated for the treatment of hypertriglyceridemia.

Material and methods: Randomized clinical trial, in volunteers with serum triglyceride levels of 200 mg/dL or more. Two treatments were distributed; 40 gr. of oat, compared to 40 gr. of flaxseed in the morning fasting in both groups, with a follow-up of four weeks with baseline measurements and final lipid profile with diet control and exercise.

Analysis of the results: Student’s t-test, was used for the comparison of means, the Wilcoxon signed-rank test was used for skewed populations. Fisher's exact test was used to compare percentages. It was considered a statistical significance of p<0.05.

Results: Thirty volunteers were studied, 15 for the oat group and 15 for the flaxseed group; two individuals from the oat group were eliminated due to the presence of minor adverse effects, leaving only 13 volunteers.

No significant differences were found when comparing the oat group against the flaxseed group in the serum triglyceride levels (p=0.247 and 0.436 at the beginning and the end, respectively), no significant difference was found in the serum triglyceride levels in the oat group (initial 298.80 ± 114.60 against 307.20 ± 126.95 at the end, p=0.798), similar results were found in the flaxseed group (initial 351.61 ± 155.17 against 303.23 ± 117.40 at the end, p=0.152). I t was found that in both groups there was significant reduction in weight.

Conclusions: the use of oats and flaxseeds were ineffective in lowering the serum triglyceride levels.


Author(s):

Francisco Hernández-Pérez, Elizabeth Corona-Tlatelpa and Emma Beatriz Medina- Cazares



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