Tapinanthus globiferus (Loranthaceae) is a plant used in traditional medicine for the treatment of rheumatism, syphilis, fever and epilepsy. In this study, the acute toxicity study revealed an oral LD50 of ≥ 5000 mg/kg. The anticonvulsant activity of the residual aqueous fraction was investigated at doses of 250, 500, and 1000 mg/ kg using the Pentylenetetrazole (PTZ) induced seizure and maximal electroshock seizure models in mice and chicks. In the PTZ induced seizure the fraction offered 62.5% protection against seizure and prolonged the onset of seizure from 54.23 ± 6.12s to 290.86 ± 14.43s. The plant decreased the minimum recovery time (MRT) after hind limb tonic extension (HTLE) from 213.4 ± 19.12s to 136 ± 16.1s in the 500 mg/kg group.
The CNS depressant effect was also studied using the Diazepam induce sleep model. The fraction used dose dependently decreased the onset of diazepam induced sleep 160.03 ± 19.24.s to 28.00 ± 7.18.s, with a marked increase in duration of sleep 39.00 ± 12.53 min to 198.17 ± 27.28 min in the 1000 mg/kg treated group.
The data obtained from this study suggest that the residual aqueous portion of the dried whole plant of Tapinanthus globiferus may possess bioactive compounds with anticonvulsant effect.
Abubakar K, Adebisi IM, Ugwah-Oguejiofor JC, Idris GO, Idris B and Mshelia HE
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