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Abstract

Antioxidant and Antidiabetic Potential Value of Farsetia jacquemontii from District Bannu, Pakistan

Objectives: Medicinal plants are a rich source for a variety of natural antioxidants and antidiabetic and have a considerable role in the treatment of many diseases throughout the world. Presently, due to beneficial effects of antioxidants and antidiabetic, particularly natural antioxidants and antidiabetic, in the treatment and prevention of diseases, there has been a considerable interest in finding natural antioxidants and antidiabetic from plant sources. The main purpose of this study was to evaluate the antioxidant and antidiabetic value and the potential of inhibiting α-amylase and α-glucosidase of Farsetia jacquemontii in district Bannu, Pakistan. Methods: Antioxidant activity was performed by using reagents; 1,1-diphenyl-2-picrylhydrazyl stable free radicals (DPPH), 2,2'-azino-bis ethylbenzthiazoline-6-sulfonic acid (ABTS) radical cation, hydrogen peroxide (H2O2) and sodium molybdate (Na2MoO4). The antidiabetic activity was performed by inhibition of α-amylase and α- galactosidase with IC50 values of 290 μg/ml and 240 μg/ml respectively. Results: The extract was found to possess antioxidant potential depending on concentration in a cell-free system. Antioxidant potential was highest against ABTS with IC50 followed by 98 μg/mL, MoO4 100 μg/mL, DPPH 149 μg/mL and H2O2 250 μg/mL. The antidiabetic activity was due to inhibition of α-amylase and α-galactosidase with IC50 values of 290 μg/ml and 240 μg/ml respectively. Conclusion: Based on the results, it can be concluded that Farsetia jacquemontii have antioxidant and antidiabetic potential.


Author(s):

Alamgir Khan, Zair Muhammad, Ihsan Ullah, Samiullah Khan, Saad Ullah Khan, Sikandar Khan, Saira Abbas, Sultan Mehmood Wazir, Muhammad Hayat and Kebin Zhang



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